Why Antidepressents Take So Long To Work

by Rachel Baker on November 18, 2013

This is an interesting look at how and why antidepressents work and why they take a long to time to start working.

The National Center for Health Statistics estimates more than one in 10 Americans over the age of 12 took antidepressants between 2005 and 2008, the last time period for which the data are available. The rate of antidepressant use increased 400 percent from 1998 to 2008.

Traditional antidepressants go after serotonin transporter proteins. These regulatory proteins take serotonin back into the nerve cell after it has been released in the process of signaling other neurons. Antidepressants keep the transporters from performing this function.

Although nowadays, most scientists feel that serotonin release and reuptake are fairly normal in depressed patients, many scientists nonetheless believe the changes in serotonin signaling caused by antidepressants, induces the alleviation of symptoms, says Gary Rudnick, professor of pharmacology at Yale School of Medicine.

http://blogs.scientificamerican.com/observations/2013/11/15/why-do-antidepressants-take-so-long-to-work/

Comments on this entry are closed.

Previous post:

Next post: